In geophysics, it is quite common to be interested in some continuous data (such as gravity) in some specific region of interest (such as Greenland). A common way to represent and analyze this data is by using spherical harmonics. Since spherical harmonics spread their energy over the entire globe, they are not usually amenable to regional use without some sort of numerical regularization in the signal inversion. This is due to the fact that spherical harmonics are orthogonal over the globe, but not the region.
Instead, we desire an orthogonal set of functions on the sphere that is both optimally concentrated in our spatial region of interest and bandlimited to a chosen degree. These functions will have most of their energy within our region, and will have minimal energy outside. For this purpose we use spherical Slepian functions, which are analogs to the classic Slepian concentration problem [Slepian, 1983; Wieczorek and Simons, 2005; Simons et al., 2006; Simons and Dahlen, 2006]. The new functions are defined in a similar way to spherical harmonics, as \begin{equation} g_\alpha(\mathbf{\hat{r}}) = \sum_{l=0}^L \sum_{m=-l}^l g_{\alpha , lm} Y_{lm}(\mathbf{\hat{r}}), \quad\quad g_{\alpha,lm} = \int_\Omega g_\alpha(\mathbf{\hat{r}}) Y_{lm}(\mathbf{\hat{r}}) \,d \Omega. \end{equation} The Slepian function coefficients, $g_{\alpha,lm}$, are found by solving the eigenvalue equation \begin{equation} \sum_{l'=0}^{L} \sum_{m'=-l'}^{l'} D_{lm,l'm'} g_{l'm'} = \lambda g_{lm}. \end{equation} If we were considering the entire sphere, then the integral of the products of spherical harmonics would be the delta function, illustrating that they are orthogonal. When we just consider the region $R$, the integrals are no longer delta functions, and instead are \begin{equation} \int_R Y_{lm}Y_{l'm'} \,d\Omega = D_{lm,l'm'}. \end{equation} Here $\mathbf{D}$ is a matrix whose elements $D_{lm,l'm'}$ are products of spherical harmonics integrated over the region $R$. By performing an eigenvalue decomposition of this matrix, we find the functions that have the most energy concentrated in our region: \begin{equation} \lambda = \frac{\displaystyle \int_R g_\alpha^2(\mathbf{\hat{r}})\,d\Omega} {\displaystyle \int_\Omega g_\alpha^2(\mathbf{\hat{r}})\,d\Omega} = \mbox{maximum}. \end{equation} We can then use a truncated sum of just these most concentrated functions as a basis for our region. Commonly we truncate up to the Shannon number, $N$, which is a function both of the region and of the bandwidth of our data: \begin{equation} N = (L+1)^2 \frac{A}{4\pi}, \end{equation} The truncated sum lets us represent the data very sparsely, yet with very good reconstruction properties within the region [Simons, 2010]: \begin{equation} {d}(\hat{\mathbf{r}})\approx \sum_{\alpha=1}^{N} d_{\alpha}\,g_{\alpha}(\hat{\mathbf{r}}) \quad\mbox{for}\quad \hat{\mathbf{r}}\in R . \end{equation} In this manner, the process is analogous to a singular-value decomposition in the pixel basis depending on inverse eigenvalues of $D$, truncated when they get large. These properties make the Slepian basis is an ideal tool to conduct estimation problems that are linear or quadratic in the data [Simons and Dahlen, 2006; Dahlen and Simons, 2008].
Below we show an example of a set of Slepian functions that are concentrated in a region around Greenland, for a certain spherical harmonic bandwidth up to degree and order 60.

Figure 1: Slepian eigenfunctions $g_1, g_2, ..., g_{12}$ that are
optimally concentrated within a region buffering Greenland by
0.5$^\circ$. Dashed line indicates the region of concentration.
Functions are bandlimited to $L = 60$ and are scaled to unit
magnitude. The parameter$\alpha$ denotes which eigenfunction is
shown. The parameter $\lambda$ is the corresponding eigenvalue for
each function, indicating the amount of concentration. Magnitude
values whose absolute values are smaller than 0.01 are left white.

Figure 2: Time series of various ($\alpha$ = 1, 5, 6, 7, 11, 20) Slepian
coefficients and their best-fit polynomial (blue lines). Each
coefficient is fit by an annual periodic and linear function, as
well as quadratic and cubic polynomial terms if those terms pass an
$F$-test for variance reduction. Shown here are the coefficient and
fitted function values with the annual periodic function subtracted
from both. The mean is removed from each time series.

Figure 3: Predicted GRACE annual mass change in the Slepian basis for
each of the first twelve eigenfunctions. Each eigenfunction,
denoted by its index $\alpha$, is scaled by the total change in that
coefficient from 1/2003-11/2011 divided by the time span (yrs),
expressed as the cm/yr water equivalent of surface density. Thus,
this represents the mass change for an average year during this time
span. The inset variable "Int" displays the integral of each
function in the concentration region within the dashed line
expressed as the mass change rate of gigatons per year.
Surface-density change of absolute value smaller than 0.1
cm/year is left white.

Figure 4: Mass change in gigatons (Gt) for the three most significant
Slepian-function terms ($\alpha$ = 1, 3, 11), which contribute more
than 70% of total mass change over the data time span. Monthly
data are drawn as the solid black lines while the $2\sigma$
uncertainty envelopes are drawn in grey. Each function has a mean
of zero but has been offset from zero for clarity.